@inproceedings{lakin2014abstract, author = {Lakin, Matthew R. and Petersen, Rasmus and Gray, Kathryn E. and Phillips, Andrew}, title = {Abstract modelling of tethered DNA circuits}, booktitle = {International Conference on DNA Computing and Molecular Programming}, year = {2014}, month = {September}, abstract = {Sequence-specific DNA interactions are a powerful means of programming nanoscale locomotion. These systems typically use a DNA track that is tethered to a surface, and molecular interactions enable a signal or cargo to traverse this track. Such low copy number systems are highly amenable to mechanized analyses such as probabilistic model checking, which requires a formal encoding. In this paper we present the first general encoding of tethered DNA species into a formal language, which allows the interactions between tethered species to be derived automatically using standard reaction rules. We apply this encoding to a previously published tethered DNA circuit architecture based on hairpin assembly reactions. This work enables automated analysis of large-scale tethered DNA circuits and, potentially, synthesis of optimized track layouts to implement specific logic functions.}, publisher = {Springer}, url = {http://approjects.co.za/?big=en-us/research/publication/abstract-modelling-of-tethered-dna-circuits/}, pages = {132-147}, volume = {8727}, edition = {International Conference on DNA Computing and Molecular Programming}, }