@article{matthews2012co-operative,
author = {Matthews, Philippa C. and Listgarten, Jennifer and Carlson, Jonathan M. and Payne, Rebecca and Huang, Kuan-Hsiang Gary and Frater, John and Goedhals, Dominique and Steyn, Dewald and Vuuren, Cloete van and Paioni, Paolo and Jooste, Pieter and Ogwu, Anthony and Shapiro, Roger and Mncube, Zenele and Ndung'u, Thumbi and Walker, Bruce D. and Heckerman, David and Goulder, Philip J. R.},
title = {Co-operative additive effects between HLA alleles in control of HIV-1},
year = {2012},
month = {October},
abstract = {Background

HLA class I genotype is a major determinant of the outcome of HIV infection, and the impact of certain alleles on HIV disease outcome is well studied. Recent studies have demonstrated that certain HLA class I alleles that are in linkage disequilibrium, such as HLA-A*74 and HLA-B*57, appear to function co-operatively to result in greater immune control of HIV than mediated by either single allele alone. We here investigate the extent to which HLA alleles - irrespective of linkage disequilibrium - function co-operatively.

Methodology/Principal Findings

We here refined a computational approach to the analysis of >2000 subjects infected with C-clade HIV first to discern the individual effect of each allele on disease control, and second to identify pairs of alleles that mediate ‘co-operative additive’ effects, either to improve disease suppression or to contribute to immunological failure. We identified six pairs of HLA class I alleles that have a co-operative additive effect in mediating HIV disease control and four hazardous pairs of alleles that, occurring together, are predictive of worse disease outcomes (q},
url = {http://approjects.co.za/?big=en-us/research/publication/co-operative-additive-effects-hla-alleles-control-hiv-1/},
pages = {e47799},
journal = {PLoS ONE},
}