@article{joesaar2019dna-based,
author = {Joesaar, Alex and Yang, Shuo and Bögels, Bas and Linden, Ardjan van der and Pieters, Pascal and Kumar, B. V. V. S. Pavan and Dalchau, Neil and Phillips, Andrew and Mann, Stephen and Greef, Tom F. A. de},
title = {DNA-based communication in populations of synthetic protocells},
year = {2019},
month = {March},
abstract = {Developing molecular communication platforms based on orthogonal communication channels is a crucial step towards engineering artificial multicellular systems. Here, we present a general and scalable platform entitled ‘biomolecular implementation of protocellular communication’ (BIO-PC) to engineer distributed multichannel molecular communication between populations of non-lipid semipermeable microcapsules. Our method leverages the modularity and scalability of enzyme-free DNA strand-displacement circuits to develop protocellular consortia that can sense, process and respond to DNA-based messages. We engineer a rich variety of biochemical communication devices capable of cascaded amplification, bidirectional communication and distributed computational operations. Encapsulating DNA strand-displacement circuits further allows their use in concentrated serum where non-compartmentalized DNA circuits cannot operate. BIO-PC enables reliable execution of distributed DNA-based molecular programs in biologically relevant environments and opens new directions in DNA computing and minimal cell technology.},
url = {http://approjects.co.za/?big=en-us/research/publication/dna-based-communication-in-populations-of-synthetic-protocells/},
journal = {Nature Nanotechnology},
}