@article{frahm2007extensive,
author = {Frahm, Nicole and Yusim, Karina and Suscovich, Todd J. and Adams, Sharon and Sidney, John and Hraber, Peter and Hewitt, Hannah S. and Linde, Caitlyn H. and Kavanagh, Daniel G. and Woodberry, Tonia and Henry, Leah M. and Faircloth, Kellie and Listgarten, Jennifer and Kadie, Carl and Jojic, Nebojsa and Sango, Kaori and Brown, Nancy V. and Pae, Eunice and Zaman, M. Tauheed and Bihl, Florian and Khatri, Ashok and John, Mina and Mallal, Simon and Marincola, Francesco M. and Walker, Bruce D. and Sette, Alessandro and Heckerman, David and Korber, Bette T. and Brander, Christian},
title = {Extensive HLA class I allele promiscuity among viral CTL epitopes},
year = {2007},
month = {September},
abstract = {Promiscuous binding of T helper epitopes to MHC class II molecules has been well established, but few examples of promiscuous class I-restricted epitopes exist. To address the extent of promiscuity of HLA class I peptides, responses to 242 well-defined viral epitopes were tested in 100 subjects regardless of the individuals' HLA type. Surprisingly, half of all detected responses were seen in the absence of the originally reported restricting HLA class I allele, and only 3% of epitopes were recognized exclusively in the presence of their original allele. Functional assays confirmed the frequent recognition of HLA class I-restricted T cell epitopes on several alternative alleles across HLA class I supertypes and encoded on different class I loci. These data have significant implications for the understanding of MHC class I-restricted antigen presentation and vaccine development.},
url = {http://approjects.co.za/?big=en-us/research/publication/extensive-hla-class-allele-promiscuity-among-viral-ctl-epitopes/},
pages = {2419-2433},
journal = {European Journal of Immunology},
volume = {37},
number = {9},
}