@article{runcie2019fast,
author = {Runcie, Daniel E. and Crawford, Lorin},
title = {Fast and flexible linear mixed models for genome-wide genetics.},
year = {2019},
month = {February},
abstract = {Linear mixed effect models are powerful tools used to account for population structure in genome-wide association studies (GWASs) and estimate the genetic architecture of complex traits. However, fully-specified models are computationally demanding and common simplifications often lead to reduced power or biased inference. We describe Grid-LMM (https://github.com/deruncie/GridLMM), an extendable algorithm for repeatedly fitting complex linear models that account for multiple sources of heterogeneity, such as additive and non-additive genetic variance, spatial heterogeneity, and genotype-environment interactions. Grid-LMM can compute approximate (yet highly accurate) frequentist test statistics or Bayesian posterior summaries at a genome-wide scale in a fraction of the time compared to existing general-purpose methods. We apply Grid-LMM to two types of quantitative genetic analyses. The first is focused on accounting for spatial variability and non-additive genetic variance while scanning for QTL; and the second aims to identify gene expression traits affected by non-additive genetic variation. In both cases, modeling multiple sources of heterogeneity leads to new discoveries.},
url = {http://approjects.co.za/?big=en-us/research/publication/fast-and-flexible-linear-mixed-models-for-genome-wide-genetics/},
pages = {1-24},
journal = {PLOS Genetics},
volume = {15},
number = {2},
}