{"id":148015,"date":"2009-02-01T00:00:00","date_gmt":"2009-02-01T00:00:00","guid":{"rendered":"https:\/\/www.microsoft.com\/en-us\/research\/msr-research-item\/a-process-model-of-actin-polymerisation\/"},"modified":"2019-03-11T11:30:40","modified_gmt":"2019-03-11T18:30:40","slug":"a-process-model-of-actin-polymerisation","status":"publish","type":"msr-research-item","link":"https:\/\/www.microsoft.com\/en-us\/research\/publication\/a-process-model-of-actin-polymerisation\/","title":{"rendered":"A Process Model of Actin Polymerisation"},"content":{"rendered":"<div class=\"asset-content\">\n<p>Actin is the monomeric subunit of actin filaments which form one of the three major cytoskeletal networks in eukaryotic cells. Actin dynamics, be it the polymerisation of actin monomers into filaments or the reverse process, plays a key role in many cellular activities such as cell motility and phagocytosis. There is a growing number of experimental, theoretical and mathematical studies on the components of actin polymerisation and depolymerisation. However, it remains a challenge to develop compositional models of actin dynamics, e.g., by using differential equations. In this paper, we propose compositional process algebra models of actin polymerisation, and present a geometric representation of these models that allows to generate movies reflecting their dynamics.<\/p>\n<\/div>\n<p><!-- .asset-content --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Actin is the monomeric subunit of actin filaments which form one of the three major cytoskeletal networks in eukaryotic cells. Actin dynamics, be it the polymerisation of actin monomers into filaments or the reverse process, plays a key role in many cellular activities such as cell motility and phagocytosis. There is a growing number of [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"msr-url-field":"","msr-podcast-episode":"","msrModifiedDate":"","msrModifiedDateEnabled":false,"ep_exclude_from_search":false,"_classifai_error":"","msr-author-ordering":null,"msr_publishername":"","msr_publisher_other":"","msr_booktitle":"","msr_chapter":"","msr_edition":"","msr_editors":"","msr_how_published":"","msr_isbn":"","msr_issue":"1","msr_journal":"Electronic Notes in Theoretical Computer Science","msr_number":"","msr_organization":"","msr_pages_string":"","msr_page_range_start":"127","msr_page_range_end":"144","msr_series":"","msr_volume":"229","msr_copyright":"","msr_conference_name":"","msr_doi":"","msr_arxiv_id":"","msr_s2_paper_id":"","msr_mag_id":"","msr_pubmed_id":"","msr_other_authors":"","msr_other_contributors":"","msr_speaker":"","msr_award":"","msr_affiliation":"","msr_institution":"","msr_host":"","msr_version":"","msr_duration":"","msr_original_fields_of_study":"","msr_release_tracker_id":"","msr_s2_match_type":"","msr_citation_count_updated":"","msr_published_date":"2009-2-1","msr_highlight_text":"","msr_notes":"","msr_longbiography":"","msr_publicationurl":"http:\/\/dx.doi.org\/10.1016\/j.entcs.2009.02.009","msr_external_url":"","msr_secondary_video_url":"","msr_conference_url":"","msr_journal_url":"","msr_s2_pdf_url":"","msr_year":0,"msr_citation_count":0,"msr_influential_citations":0,"msr_reference_count":0,"msr_s2_match_confidence":0,"msr_microsoftintellectualproperty":true,"msr_s2_open_access":false,"msr_s2_author_ids":[],"msr_pub_ids":[],"msr_hide_image_in_river":0,"footnotes":""},"msr-research-highlight":[],"research-area":[13546],"msr-publication-type":[193715],"msr-publisher":[],"msr-focus-area":[],"msr-locale":[268875],"msr-post-option":[],"msr-field-of-study":[],"msr-conference":[],"msr-journal":[],"msr-impact-theme":[],"msr-pillar":[],"class_list":["post-148015","msr-research-item","type-msr-research-item","status-publish","hentry","msr-research-area-computational-sciences-mathematics","msr-locale-en_us"],"msr_publishername":"","msr_edition":"","msr_affiliation":"","msr_published_date":"2009-2-1","msr_host":"","msr_duration":"","msr_version":"","msr_speaker":"","msr_other_contributors":"","msr_booktitle":"","msr_pages_string":"","msr_chapter":"","msr_isbn":"","msr_journal":"Electronic Notes in Theoretical Computer Science","msr_volume":"229","msr_number":"","msr_editors":"","msr_series":"","msr_issue":"1","msr_organization":"","msr_how_published":"","msr_notes":"","msr_highlight_text":"","msr_release_tracker_id":"","msr_original_fields_of_study":"","msr_download_urls":"","msr_external_url":"","msr_secondary_video_url":"","msr_longbiography":"","msr_microsoftintellectualproperty":1,"msr_main_download":"224332","msr_publicationurl":"http:\/\/dx.doi.org\/10.1016\/j.entcs.2009.02.009","msr_doi":"","msr_publication_uploader":[{"type":"file","viewUrl":"https:\/\/www.microsoft.com\/en-us\/research\/wp-content\/uploads\/2009\/02\/FBTC08.pdf","id":"224332","title":"FBTC08.pdf","label_id":"243109","label":0},{"type":"url","viewUrl":"false","id":"false","title":"http:\/\/dx.doi.org\/10.1016\/j.entcs.2009.02.009","label_id":"243109","label":0}],"msr_related_uploader":"","msr_citation_count":0,"msr_citation_count_updated":"","msr_s2_paper_id":"","msr_influential_citations":0,"msr_reference_count":0,"msr_arxiv_id":"","msr_s2_author_ids":[],"msr_s2_open_access":false,"msr_s2_pdf_url":null,"msr_attachments":[{"id":0,"url":"http:\/\/dx.doi.org\/10.1016\/j.entcs.2009.02.009"}],"msr-author-ordering":[{"type":"user_nicename","value":"Luca Cardelli","user_id":32743,"rest_url":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/microsoft-research\/v1\/researchers?person=Luca Cardelli"},{"type":"text","value":"Emmanuelle Caron","user_id":0,"rest_url":false},{"type":"text","value":"Philippa Gardner","user_id":0,"rest_url":false},{"type":"text","value":"Ozan Kahramano\u011fullar\u0131","user_id":0,"rest_url":false},{"type":"user_nicename","value":"Andrew Phillips","user_id":31075,"rest_url":"https:\/\/www.microsoft.com\/en-us\/research\/wp-json\/microsoft-research\/v1\/researchers?person=Andrew Phillips"}],"msr_impact_theme":[],"msr_research_lab":[],"msr_event":[],"msr_group":[],"msr_project":[544545,170002],"publication":[],"video":[],"msr-tool":[],"msr_publication_type":"article","related_content":{"projects":[{"ID":544545,"post_title":"Station B","post_name":"stationb","post_type":"msr-project","post_date":"2019-03-11 15:56:07","post_modified":"2021-09-28 09:10:36","post_status":"publish","permalink":"https:\/\/www.microsoft.com\/en-us\/research\/project\/stationb\/","post_excerpt":"Our work on the Station B project has now been retired. We continue to actively explore the exciting intersection of computing and life sciences, with other projects located on\u00a0www.microsoft.com\/research. Building a platform for programming biology The ability to program biology could enable fundamental breakthroughs across a broad range of industries, including medicine, agriculture, food, construction, textiles, materials and chemicals. It could also help lay the foundation for a future bioeconomy based on sustainable technology. 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