{"id":159014,"date":"2009-08-03T00:00:00","date_gmt":"2009-08-03T00:00:00","guid":{"rendered":"https:\/\/www.microsoft.com\/en-us\/research\/msr-research-item\/systems-analyses-of-circadian-networks\/"},"modified":"2018-10-16T21:20:31","modified_gmt":"2018-10-17T04:20:31","slug":"systems-analyses-of-circadian-networks","status":"publish","type":"msr-research-item","link":"https:\/\/www.microsoft.com\/en-us\/research\/publication\/systems-analyses-of-circadian-networks\/","title":{"rendered":"Systems analyses of circadian networks"},"content":{"rendered":"<div class=\"asset-content\">\n<p>The circadian clock is a 24 hour timing device that co-ordinates biological activity with day\/night cycles. The long history of systems analysis of circadian biology extends back to the first half of the last century when theoretical studies based on physiological experiments predicted the essential network properties, architecture and performance of circadian oscillators long before the first genetic components were isolated in the second half of the century. Systems approaches have continued to be important in analysing the circadian network in the model plant Arabidopsis thaliana and in mammals. We describe how systems analyses of transcriptional changes have led to formal mathematical models of circadian oscillators. Predictions within these mathematical models have been used to identify potential new components of circadian systems. Cross-referencing circadian regulation of transcript abundance with transcriptomic responses to abiotic and biotic signals has increased understanding of the nature of circadian clocks and their significance in regulating the daily life of plants and animals. We also highlight the need for systems analyses of the circadian regulation of proteins, metabolites and other physiological activities such as ion channel regulation.<\/p>\n<\/div>\n<p><!-- .asset-content --><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The circadian clock is a 24 hour timing device that co-ordinates biological activity with day\/night cycles. The long history of systems analysis of circadian biology extends back to the first half of the last century when theoretical studies based on physiological experiments predicted the essential network properties, architecture and performance of circadian oscillators long before [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"msr-url-field":"","msr-podcast-episode":"","msrModifiedDate":"","msrModifiedDateEnabled":false,"ep_exclude_from_search":false,"_classifai_error":"","msr-author-ordering":null,"msr_publishername":"The Royal Society of Chemistry 2009","msr_publisher_other":"","msr_booktitle":"","msr_chapter":"","msr_edition":"","msr_editors":"","msr_how_published":"","msr_isbn":"","msr_issue":"","msr_journal":"Molecular Biosystems","msr_number":"","msr_organization":"","msr_pages_string":"1502-1511","msr_page_range_start":"1502","msr_page_range_end":"1511","msr_series":"","msr_volume":"5","msr_copyright":"","msr_conference_name":"","msr_doi":"10.1039\/B907714F","msr_arxiv_id":"","msr_s2_paper_id":"","msr_mag_id":"","msr_pubmed_id":"","msr_other_authors":"Katharine E Hubbard, Fiona C Robertson, Alex A R Webb","msr_other_contributors":"","msr_speaker":"","msr_award":"","msr_affiliation":"","msr_institution":"Department of Plant Sciences, University of Cambridge, Downing Street, Cambridge, UK CB2 3EA.","msr_host":"","msr_version":"","msr_duration":"","msr_original_fields_of_study":"","msr_release_tracker_id":"","msr_s2_match_type":"","msr_citation_count_updated":"","msr_published_date":"2009-08-03","msr_highlight_text":"","msr_notes":"","msr_longbiography":"","msr_publicationurl":"http:\/\/www.rsc.org\/publishing\/journals\/MB\/article.asp?doi=b907714f","msr_external_url":"","msr_secondary_video_url":"","msr_conference_url":"","msr_journal_url":"","msr_s2_pdf_url":"","msr_year":2009,"msr_citation_count":0,"msr_influential_citations":0,"msr_reference_count":0,"msr_s2_match_confidence":0,"msr_microsoftintellectualproperty":true,"msr_s2_open_access":false,"msr_s2_author_ids":[],"msr_pub_ids":[],"msr_hide_image_in_river":0,"footnotes":""},"msr-research-highlight":[],"research-area":[13546],"msr-publication-type":[193715],"msr-publisher":[],"msr-focus-area":[],"msr-locale":[268875],"msr-post-option":[],"msr-field-of-study":[],"msr-conference":[],"msr-journal":[],"msr-impact-theme":[],"msr-pillar":[],"class_list":["post-159014","msr-research-item","type-msr-research-item","status-publish","hentry","msr-research-area-computational-sciences-mathematics","msr-locale-en_us"],"msr_publishername":"The Royal Society of Chemistry 2009","msr_edition":"","msr_affiliation":"","msr_published_date":"2009-08-03","msr_host":"","msr_duration":"","msr_version":"","msr_speaker":"","msr_other_contributors":"","msr_booktitle":"","msr_pages_string":"1502-1511","msr_chapter":"","msr_isbn":"","msr_journal":"Molecular Biosystems","msr_volume":"5","msr_number":"","msr_editors":"","msr_series":"","msr_issue":"","msr_organization":"","msr_how_published":"","msr_notes":"","msr_highlight_text":"","msr_release_tracker_id":"","msr_original_fields_of_study":"","msr_download_urls":"","msr_external_url":"","msr_secondary_video_url":"","msr_longbiography":"","msr_microsoftintellectualproperty":1,"msr_main_download":"","msr_publicationurl":"http:\/\/www.rsc.org\/publishing\/journals\/MB\/article.asp?doi=b907714f","msr_doi":"10.1039\/B907714F","msr_publication_uploader":[{"type":"url","title":"http:\/\/www.rsc.org\/publishing\/journals\/MB\/article.asp?doi=b907714f","viewUrl":false,"id":false,"label_id":0},{"type":"doi","title":"10.1039\/B907714F","viewUrl":false,"id":false,"label_id":0}],"msr_related_uploader":"","msr_citation_count":0,"msr_citation_count_updated":"","msr_s2_paper_id":"","msr_influential_citations":0,"msr_reference_count":0,"msr_arxiv_id":"","msr_s2_author_ids":[],"msr_s2_open_access":false,"msr_s2_pdf_url":null,"msr_attachments":[{"id":0,"url":"http:\/\/www.rsc.org\/publishing\/journals\/MB\/article.asp?doi=b907714f"}],"msr-author-ordering":[{"type":"text","value":"Katharine E. 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We continue to actively explore the exciting intersection of computing and life sciences, with other projects located on\u00a0www.microsoft.com\/research. Building a platform for programming biology The ability to program biology could enable fundamental breakthroughs across a broad range of industries, including medicine, agriculture, food, construction, textiles, materials and chemicals. It could also help lay the foundation for a future bioeconomy based on sustainable technology. 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