{"id":343325,"date":"2016-12-29T16:20:27","date_gmt":"2016-12-30T00:20:27","guid":{"rendered":"https:\/\/www.microsoft.com\/en-us\/research\/?post_type=msr-research-item&#038;p=343325"},"modified":"2018-10-16T21:38:47","modified_gmt":"2018-10-17T04:38:47","slug":"early-immune-adaptation-hiv-1-revealed-population-level-approaches","status":"publish","type":"msr-research-item","link":"https:\/\/www.microsoft.com\/en-us\/research\/publication\/early-immune-adaptation-hiv-1-revealed-population-level-approaches\/","title":{"rendered":"Early immune adaptation in HIV-1 revealed by population-level approaches"},"content":{"rendered":"<div id=\"ASec1\" class=\"AbstractSection\">\n<p class=\"Para\">The reproducible nature of HIV-1 escape from HLA-restricted CD8+ T-cell responses allows the identification of HLA-associated viral polymorphisms \u201cat the population level\u201d \u2013 that is, via analysis of cross-sectional, linked HLA\/HIV-1 genotypes by statistical association. However, elucidating their timing of selection traditionally requires detailed longitudinal studies, which are challenging to undertake on a large scale. We investigate whether the extent and relative timecourse of immune-driven HIV adaptation can be inferred via comparative cross-sectional analysis of independent early and chronic infection cohorts.<\/p>\n<\/div>\n<div id=\"ASec2\" class=\"AbstractSection\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>The reproducible nature of HIV-1 escape from HLA-restricted CD8+ T-cell responses allows the identification of HLA-associated viral polymorphisms \u201cat the population level\u201d \u2013 that is, via analysis of cross-sectional, linked HLA\/HIV-1 genotypes by statistical association. However, elucidating their timing of selection traditionally requires detailed longitudinal studies, which are challenging to undertake on a large scale. [&hellip;]<\/p>\n","protected":false},"featured_media":0,"template":"","meta":{"msr-url-field":"","msr-podcast-episode":"","msrModifiedDate":"","msrModifiedDateEnabled":false,"ep_exclude_from_search":false,"_classifai_error":"","footnotes":""},"msr-content-type":[3],"msr-research-highlight":[],"research-area":[13553],"msr-publication-type":[193715],"msr-product-type":[],"msr-focus-area":[],"msr-platform":[],"msr-download-source":[],"msr-locale":[268875],"msr-post-option":[],"msr-field-of-study":[],"msr-conference":[],"msr-journal":[],"msr-impact-theme":[],"msr-pillar":[],"class_list":["post-343325","msr-research-item","type-msr-research-item","status-publish","hentry","msr-research-area-medical-health-genomics","msr-locale-en_us"],"msr_publishername":"","msr_edition":"Retrovirology","msr_affiliation":"","msr_published_date":"2014-08-29","msr_host":"","msr_duration":"","msr_version":"","msr_speaker":"","msr_other_contributors":"","msr_booktitle":"","msr_pages_string":"","msr_chapter":"","msr_isbn":"","msr_journal":"Retrovirology","msr_volume":"","msr_number":"","msr_editors":"","msr_series":"","msr_issue":"","msr_organization":"","msr_how_published":"","msr_notes":"","msr_highlight_text":"","msr_release_tracker_id":"","msr_original_fields_of_study":"","msr_download_urls":"","msr_external_url":"","msr_secondary_video_url":"","msr_longbiography":"","msr_microsoftintellectualproperty":1,"msr_main_download":"","msr_publicationurl":"http:\/\/retrovirology.biomedcentral.com\/articles\/10.1186\/s12977-014-0064-1","msr_doi":"10.1186\/s12977-014-0064-1","msr_publication_uploader":[{"type":"url","title":"http:\/\/retrovirology.biomedcentral.com\/articles\/10.1186\/s12977-014-0064-1","viewUrl":false,"id":false,"label_id":0},{"type":"doi","title":"10.1186\/s12977-014-0064-1","viewUrl":false,"id":false,"label_id":0}],"msr_related_uploader":"","msr_attachments":[{"id":0,"url":"http:\/\/retrovirology.biomedcentral.com\/articles\/10.1186\/s12977-014-0064-1"}],"msr-author-ordering":[{"type":"text","value":"Eric 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