Dr. Shaun Murphy (Freddie Highmore), a young surgeon with autism and savant syndrome, has worked tirelessly to prove to his colleagues that his extraordinary medical gifts will save lives. All while planning a wedding, season five sees Shaun navigate more uncertainties as a major change comes to St. Bonaventure. Meanwhile, the rest of the team must also navigate the complexities of their own changing relationships as they continue to deal with life and death situations.