Early immune adaptation in HIV-1 revealed by population-level approaches
- Eric Martin ,
- Jonathan M. Carlson ,
- Anh Q Le ,
- Denis R Chopera ,
- Rachel McGovern ,
- Manal A Rahman ,
- Carmond Ng ,
- Heiko Jessen ,
- Anthony D Kelleher ,
- Martin Markowitz ,
- Todd M Allen ,
- MJ Milloy ,
- Mary Carrington ,
- Mark A Wainberg ,
- Zabrina L Brumme
Retrovirology |
The reproducible nature of HIV-1 escape from HLA-restricted CD8+ T-cell responses allows the identification of HLA-associated viral polymorphisms “at the population level” – that is, via analysis of cross-sectional, linked HLA/HIV-1 genotypes by statistical association. However, elucidating their timing of selection traditionally requires detailed longitudinal studies, which are challenging to undertake on a large scale. We investigate whether the extent and relative timecourse of immune-driven HIV adaptation can be inferred via comparative cross-sectional analysis of independent early and chronic infection cohorts.